Using a Beacon grant provided by the Office of the National Coordinator of Health IT, the Mayo Clinic is building what may be the next generation of health information exchanges with a group of healthcare providers in southeast Minnesota. In this real-world demonstration, Mayo will apply the computer tools it is developing through a federal SHARP grant to create new methods of mining electronic health record data. "We're building a patient data repository for southeast Minnesota that will execute on a lot of the promise and principles we're articulating in our SHARP grant," said Christopher Chute, MD, a Mayo Clinic epidemiologist and the principal investigator on Mayo's SHARP grant. Mayo is using the government's CONNECT software to establish the HIE. The world-famous group practice also is working with the pioneering Indiana Health Information Exchange to build a data repository like the one in Indianapolis.